반응 #1994248

반응 방정식

8-nitro-2-naphthylquinoline

sodium borohydride

HCl

→

crystalline solid

수율 135.5%

8-Amino-2-naphthylquinoline

수율 135.5%

용매

methanol

반응 조건

후처리

1. 1
   workup.STIRRINGAfter stirring for 2 h
2. 2
   기타The solvent is then removed
3. 3
   세척the resultant residue is washed vigorously with water
4. 4
   기타recrystallised from dioxane
5. 5
   여과The precipitate is filtered
6. 6
   기타dried in vacuo

실험 절차

12.6 g (42 mmol) of 8-nitro-2-naphthylquinoline and 1.99 g of Pd/C (10%) are suspended in 200 ml of methanol. 8.4 g (222 mmol) of sodium borohydride are added in portions with stirring at 0° C. After stirring for 2 h, the clear solution is neutralised using dilute HCl. The solvent is then removed, and the resultant residue is washed vigorously with water and recrystallised from dioxane. The precipitate is filtered and dried in vacuo, giving 9.9 g (56.9 mmol) of crystalline solid. The overall yield is 88%.

출처