반응 #1994

ord-722fc1c8e1ff43a08b3a226da745e8d4

반응 방정식

CC(C)(C)OC(=O)N1CCC[C@H]1[C@H](CCO)C[N+](=O)[O-]
ether
CC(C)(C)OC(=O)N1CCC[C@H]1[C@H](CCO)C[N+](=O)[O-]
3-(R)-(1-BOC-2-(S)-pyrrolidinyl)-4-nitrobutanol
→
CC(C)(C)OC(=O)N1CCC[C@H]1[C@@H]1CCNC1
3-(R)-(1-BOC-pyrrolidin-2-(S)-yl)pyrrolidine

반응물

CC(C)(C)OC(=O)N1CCC[C@H]1[C@H](CCO)C[N+](=O)[O-]
ether
CC(C)(C)OC(=O)N1CCC[C@H]1[C@H](CCO)C[N+](=O)[O-]
3-(R)-(1-BOC-2-(S)-pyrrolidinyl)-4-nitrobutanol

시약

[Pd]
Pd/C

용매

CO
methanol

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타to give the tile compound

실험 절차

The ether compound from step 471a was treated by hydrogenation at 4 atm H2 over Pd/C in methanol to give the tile compound.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US05726182uspto-grants-1998_03