반응 #1990285

반응 방정식

potassium hydroxide

dimethylformamide

beta-carboline-3-carboxaldehyde

hydroxylamino-hydrochloride

→

beta-carboline-3-carboxaldehyde-oxime

수율 67.3%

용매

methanol

반응 조건

후처리

1. 1
   기타After evaporation, 50 ml of water
2. 2
   workup.ADDITIONis added
3. 3
   여과The reaction product is filtered off
4. 4
   온도6.9 g of the air-dried product is heated in the steam bath together with 35 ml of 2 propanol
5. 5
   온도after cooling
6. 6
   여과is filtered off

실험 절차

A solution of 3.1 g of potassium hydroxide in 40 ml of methanol is added to a mixture of 150 ml of dimethylformamide, 6.9 g of beta-carboline-3-carboxaldehyde and 3.1 g of hydroxylamino-hydrochloride. The reaction mixture is allowed to stand at room temperature overnight. After evaporation, 50 ml of water is added. The reaction product is filtered off. 6.9 g of the air-dried product is heated in the steam bath together with 35 ml of 2 propanol and, after cooling, is filtered off. 5 g of beta-carboline-3-carboxaldehyde-oxime with a melting point of 229°-231° C. is obtained.

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