반응 #1988

반응 방정식

K2CO3

compound

2-benzyl-4,6-dioxooctahydropyrrolo[3.4-c]pyridine

benzyl bromide

→

title compound

수율 111.4%

2,5-dibenzyl-4,6-dioxooctahydropyrrolo[3.4-c]pyridine

수율 111.4%

용매

DMF

ethyl acetate

반응 조건

후처리

1. 1
   세척was washed with water and brine
2. 2
   기타dried
3. 3
   농축concentrated

실험 절차

To a mixture of 905 mg of K2CO3 and 400 mg of the compound from step 457b in 5 mL of DMF was added 308 mg of benzyl bromide, and the reaction mixture was stirred at room temperature under N2 for 6.5 hours. The mixture was diluted with ethyl acetate, which was washed with water and brine, dried and concentrated to give 610 mg of the title compound.

출처