반응 #1985941

반응 방정식

bromine

4-acetoxy-3-methoxybenzaldehyde

sodium acetate

iodine

→

desired product

4-Acetoxy-6-bromo-3-methoxybenzaldehyde

용매

water

acetic acid

반응 조건

후처리

1. 1
   workup.STIRRINGstirred at room temperature for 3 days
2. 2
   여과filtered
3. 3
   workup.DISSOLUTIONThe solid is dissolved in toluene
4. 4
   세척the solution washed with brine
5. 5
   건조dried over magnesium sulfate
6. 6
   여과filtered
7. 7
   농축concentrated in vacuo
8. 8
   기타The residue is recrystallized twice from hexanes

실험 절차

To a mixture of 4-acetoxy-3-methoxybenzaldehyde (75.7 g), anhydrous sodium acetate (76 g) and iodine (0.8 g) in acetic acid (300 ml) is added bromine (21 ml). The mixture is warmed to 45° C. for about 1 hour, then stirred stirred at room temperature for 3 days, poured into water (700 ml) and filtered. The solid is dissolved in toluene and the solution washed with brine, dried over magnesium sulfate, filtered and concentrated in vacuo. The residue is recrystallized twice from hexanes to give the desired product.

출처