반응 #1985937

반응 방정식

ammonium hydroxide

bis-[5-(2-methoxycarbonylethyl)-3-[5-(2-methoxycarbonylethyl)-2-hydroxybenzyl]2-hydroxyphenyl]methane

sodium hydroxide

→

desired product

Bis-[5-(2-carboxyethyl)-3-[5-(2-carboxyethyl)-2-hydroxybenzyl]2-hydroxyphenyl]methane

용매

methanol

반응 조건

후처리

1. 1
   기타The mixture is quenched with dilute aqueous hydrochloric acid (HCl)
2. 2
   기타The mixture is quenched as above and the organic soluble material flash
3. 3
   기타chromatographed
4. 4
   세척eluting with 10% methanol in chloroform
5. 5
   기타The product so obtained

실험 절차

A solution of bis-[5-(2-methoxycarbonylethyl)-3-[5-(2-methoxycarbonylethyl)-2-hydroxybenzyl]2-hydroxyphenyl]methane (0.10 g) in methanol (2 ml) is stirred with 10% aqueous sodium hydroxide (NaOH) (1 ml) at room temperature. The mixture is quenched with dilute aqueous hydrochloric acid (HCl) and the organic soluble material retreated as above. The mixture is quenched as above and the organic soluble material flash chromatographed, eluting with 10% methanol in chloroform. The product so obtained is treated with ammonium hydroxide solution and lyophilized to give the desired product as the ammonium salt, m.p. 150° C. (dec.).

출처