반응 #1982
ord-7b48bd4f78a1409eb2c2a20f041bf0c4
반응 방정식
2-(trifluoromethyl)acrylic acid
N-benzyl-N-(methoxymethyl)-trimethylsilylmethylamine
trifluoroacetic acid
→
title product
1-benzyl-3-trifluoromethylpyrrolidine-3-carboxylic acid
반응물
시약
없음
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타The product was removed by filtration
- 2세척washed
- 3기타dried
실험 절차
A 2.48 g sample of 2-(trifluoromethyl)acrylic acid was dissolved in 40 mL of dry methylene chloride, and a solution of 4.75 g of N-benzyl-N-(methoxymethyl)-trimethylsilylmethylamine in 20 mL of dry methylene chloride was added dropwise under N2 at 0° C. To this mixture was added 2 mL of trifluoroacetic acid, and the mixture was stirred for 2 hours at room temperature. The product was removed by filtration, washed and dried to give the title product.