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1-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)ethanone

1-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)ethanone

2-(aminooxy)ethanol

→

title compound

수율 21.0%

(E)-1-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]-triazolo[4,5-b]pyrazin-6-yl)ethanone O-2-hydroxyethyl oxime

수율 21.0%

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후처리

1. 1
   기타as described in the synthesis of example 22

실험 절차

The title compound was prepared from 1-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)ethanone (22.4) and 2-(aminooxy)ethanol in 21% yield using the same procedure as described in the synthesis of example 22. 1H-NMR (400 MHz, CD2Cl2) δ ppm 9.40 (s, 1H), 8.91 (m, 1H), 8.18 (d, 2H), 7.95 (d, 1H), 7.85 (dd, 1H), 7.45 (dd, 1H), 6.13 (s, 2H), 4.46 (t, 2H), 3.97 (t, 2H), 2.39 (s, 3H). LCMS (method A): [MH]+=364, tR=4.28 min.

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