반응 #1975270

반응 방정식

cerium chloride

sodium iodide

1-(benzo[d][1,3]dioxol-5-yl)-2-bromoethanone

N-benzyl-4-piperidone

→

white crystal

수율 44.9%

N-benzyl-4-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-4-piperidinol hydrochloride

수율 44.9%

용매

tetrahydrofuran

tetrahydrofuran

반응 조건

후처리

1. 1
   기타to form a suspension
2. 2
   workup.ADDITIONthe solution is added dropwise to the above suspension

실험 절차

Anhydrous cerium chloride (0.99 g, 4.0 mmol) and sodium iodide (1.8 g of, 12.0 mmol) are added to 10 ml of anhydrous tetrahydrofuran as a solvent to form a suspension. Dissolving 0.97 g (4.0 mmol) of 1-(benzo[d][1,3]dioxol-5-yl)-2-bromoethanone and 0.76 g (4.0 mmol) of N-benzyl-4-piperidone into 10 ml of anhydrous tetrahydrofuran, and the solution is added dropwise to the above suspension and reacting at room temperature for 2 hours. Operating according to the post-treatment procedure in General Method three to obtain 0.70 g of a white crystal, with yield of 42.9%.

출처