반응 #1973924

반응 방정식

Bupivacaine hydrochloride

sodium hydroxide

→

Bupivacaine

용매

water

반응 조건

후처리

1. 1
   기타to precipitate the Bupivacaine base
2. 2
   여과The precipitated product was filtered
3. 3
   세척further washed with DI water for at least three times
4. 4
   기타The precipitated product was dried at ca. 40° C. in vacuum for 24 hours

실험 절차

Bupivacaine hydrochloride (Sigma-Aldrich Corporation, St. Louis, Mo.) was dissolved in de-ionized (DI) water at a concentration of 40 mg/ml (saturation). A calculated amount of sodium hydroxide (in the form of 1 N solution) was added to the solution and the pH of the final mixtures was adjusted to ten to precipitate the Bupivacaine base. The precipitated product was filtered, and further washed with DI water for at least three times. The precipitated product was dried at ca. 40° C. in vacuum for 24 hours.

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