반응 #1973206

반응 방정식

2-[2-[(6-Bromohexyl)oxy]ethyl]pyridine

benzylamine

→

title compound

N-[6-[2-(2-Pyridinyl)ethoxy]hexyl]benzenemethanamine

반응 조건

후처리

1. 1
   온도After 1 h at 140° the reaction mixture was cooled
2. 2
   기타partitioned between 2M sodium hydroxyde (100 ml) and ether (100 ml)
3. 3
   세척The organic layer was washed with water and brine
4. 4
   기타dried
5. 5
   농축concentrated to a yellow oil
6. 6
   기타The excess benzylamine was removed by distillation under reduced pressure

실험 절차

2-[2-[(6-Bromohexyl)oxy]ethyl]pyridine (6.3 g) was added to benzylamine (20 ml) at 140° under nitrogen. After 1 h at 140° the reaction mixture was cooled and partitioned between 2M sodium hydroxyde (100 ml) and ether (100 ml). The organic layer was washed with water and brine, dried and concentrated to a yellow oil. The excess benzylamine was removed by distillation under reduced pressure to leave the title compound as a yellow oil (6.8 g), t.l.c. (System A 80:20:2) Rf 0.44.

출처