반응 #1970955

반응 방정식

4-methylaminomethyl-nitrobenzene

2-(2-methoxy-ethoxy)-ethyl chloride

→

4-[(N-(2-(2-methoxy-ethoxy)-ethyl)-N-methyl-amino)-methyl]-nitrobenzene

용매

dimethylformamide

반응 조건

후처리

1. 1
   기타is removed
2. 2
   세척The organic phase is washed with water
3. 3
   건조dried over sodium sulphate
4. 4
   기타After the elimination of the solvent the residue is purified over an aluminium oxide column (activity 2-3) with toluene/ethyl acetate 5:1 as eluant

실험 절차

5.0 g of 4-methylaminomethyl-nitrobenzene are dissolved in 30 ml of dimethylformamide and 4.6 g of 2-(2-methoxy-ethoxy)-ethyl chloride are added. After six hours' stirring at 100° C. the solvent is removed and the residue is taken up in ethyl acetate. The organic phase is washed with water and dried over sodium sulphate. After the elimination of the solvent the residue is purified over an aluminium oxide column (activity 2-3) with toluene/ethyl acetate 5:1 as eluant.

출처