반응 #1969493

반응 방정식

2-(4-acetylamino-phenoxy)-propionic acid methyl ester

2-(4-Acetylamino-phenoxy)-propionic acid methyl ester

→

63

수율 98.1%

2-(4-Amino-phenoxy)-propionic acid

수율 98.1%

용매

hydrochloric acid

반응 조건

후처리

1. 1
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled in vacuum
2. 2
   여과filtered hot
3. 3
   여과filtered
4. 4
   기타dried

실험 절차

To a mixture 2-(4-acetylamino-phenoxy)-propionic acid methyl ester 62 (320 grams, 1.35 mol) in concentrated hydrochloric acid (8 liters) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 63 (240 grams, 81.7%) as a brown powder. The melting point was found to be 175-180° C.

출처