반응 #1964624

반응 방정식

2-fluoro-4-[4-(6-fluoro-1H-benzimidazol-2-yl)-carbazol-9-yl]benzonitrile

potassium carbonate

sodium hydroxide

hydrogen peroxide

cyclohexylamine

→

2-cyclohexylamino-4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]benzamide

용매

dimethyl sulphoxide

ethanol

반응 조건

후처리

1. 1
   기타obtained
2. 2
   기타After treatment and purification as in stage 3 of Example 3, 40 mg of 2-cyclohexylamino-4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]benzamide
3. 3
   기타are thus obtained in the form of a white solid

실험 절차

The process is carried out as in stage 3 of Example 3, but using 100 mg of 2-fluoro-4-[4-(6-fluoro-1H-benzimidazol-2-yl)-carbazol-9-yl]benzonitrile, obtained according to stage 2 of Example 3, 263 mg of potassium carbonate and 94 mg of cyclohexylamine in 0.8 ml of dimethyl sulphoxide. 0.4 ml of a 1M aqueous solution of sodium hydroxide, 0.4 ml of a 30% aqueous solution of hydrogen peroxide and 2 ml of ethanol are then added to the reaction medium. After treatment and purification as in stage 3 of Example 3, 40 mg of 2-cyclohexylamino-4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]benzamide are thus obtained in the form of a white solid, the characteristics of which are the following:

출처