반응 #1960517

반응 방정식

Naproxen

→

2-(6-hydroxy-naphthalen-2-yl)-propionic acid

수율 81.0%

용매

HBr

반응 조건

후처리

1. 1
   온도was refluxed for 10 Hours
2. 2
   workup.ADDITIONpoured onto ice water (3000 ml)
3. 3
   여과Crude 2-(6-hydroxy-naphthalen-2-yl)-propionic acid was filtered
4. 4
   기타dried
5. 5
   기타recrystallised from a mixture of ethyl acetate and hexane

실험 절차

A mixture of Naproxen (500 grams) and 48% HBr solution (1500 ml) was refluxed for 10 Hours, poured onto ice water (3000 ml), and stirred for 30 minutes. Crude 2-(6-hydroxy-naphthalen-2-yl)-propionic acid was filtered, dried and recrystallised from a mixture of ethyl acetate and hexane to give pure 2-(6-hydroxy-naphthalen-2-yl)-propionic acid (380 grams, 81%) as a white powder with a melting point of 186-188° C.

출처