반응 #1955

반응 방정식

water

4-chloro-5-fluoro-2-picoline

product

4-Chloro-5-fluoro-2-picoline

t-butylhypochlorite

→

title compound

3,4-Dichloro-5-fluoro-2-picoline

용매

chloroform

반응 조건

후처리

1. 1
   추출the resultant aqueous mixture is extracted with methylene chloride
2. 2
   건조The organic solution is dried over anhydrous magnesium sulfate
3. 3
   여과filtered
4. 4
   농축concentrated under reduced pressure
5. 5
   workup.DISTILLATIONdistilled

실험 절차

To 0.87 g (6 mmol) of 4-chloro-5-fluoro-2-picoline, the product of Example 66, in 20 mL of chloroform cooled to -45° C., is added 0.75 mL of t-butylhypochlorite. The reaction mixture is stirred at -45° C. for 2 hours and at 0° C. for 2 hours. The reaction mixture is then poured into water and the resultant aqueous mixture is extracted with methylene chloride. The organic solution is dried over anhydrous magnesium sulfate, filtered, concentrated under reduced pressure and distilled to afford the title compound.

출처