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41b

8-Bromo-2-(3-fluoro-4-methoxyphenyl)-6-methoxyquinolin-4-ol

4-cyanophenylboronic acid

→

8-(4-Cyanophenyl)-2-(3-fluoro-4-methoxyphenyl)-6-methoxyquinolin-4-ol

수율 56.0%

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실험 절차

This compound was prepared from 41b using 4-cyanophenylboronic acid according to method P. Orange solid; Yield: 56%; mp 248-250° C.; 1H NMR (300 MHz, DMSO-d6) δ 3.89 (s, 3H), 3.94 (s, 3H), 7.28 (t, J=8.8 Hz, 1H), 7.36 (s, 1H), 7.44 (d, J=2.9 Hz, 1H), 7.53 (d, J=2.9 Hz, 1H), 7.75-7.79 (m, 2H), 7.97 (br s, 4H), 11.50 (s, 1H); MS (ESI) m/z 401 ([M+H]+). Anal. Calcd for C24H17FN2O3: C, 71.99; H, 4.28; N, 7.00. Found: C, 71.55; H, 4.47; N, 6.60.

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