반응 #1953567

반응 방정식

[(1-chloro-4-methoxy-isoquinoline-3-carbonyl)-amino]-acetic acid methyl ester

KOH

→

title compound

[(1-Chloro-4-methoxy-isoquinoline-3-carbonyl)-amino]-acetic acid

용매

EtOH

반응 조건

후처리

1. 1
   기타Then the solvent was evaporated in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in water (2 ml)
3. 3
   workup.ADDITIONthe pH of the solution was adjusted to 2-3 by the addition of aqueous 1N HCl
4. 4
   추출The mixture was extracted with EtOAc (4×10 ml)
5. 5
   건조phases were dried over MgSO4
6. 6
   기타evaporated in vacuo

실험 절차

A mixture of [(1-chloro-4-methoxy-isoquinoline-3-carbonyl)-amino]-acetic acid methyl ester (21 mg, 0.07 mmol), KOH (23 mg, 0.35 mmol) and EtOH (1 ml) was stirred at ambient temperature for 3 h. Then the solvent was evaporated in vacuo. The residue was dissolved in water (2 ml) and the pH of the solution was adjusted to 2-3 by the addition of aqueous 1N HCl. The mixture was extracted with EtOAc (4×10 ml). The combined org. phases were dried over MgSO4 and evaporated in vacuo to give the title compound as a slightly yellowish solid (18 mg); MS-(+)-ion: M+1=295.0.

출처