반응 #1951851

반응 방정식

4-chloro-3-trifluoromethylphenyl-isothiocyanate

7-(4-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one

→

title compound

수율 82.0%

1-(4-(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-7-yl-oxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)thiourea

수율 82.0%

용매

THF

반응 조건

후처리

1. 1
   기타The solvent was evaporated
2. 2
   세척the solid residue was washed with DCM

실험 절차

A mixture of 4-chloro-3-trifluoromethylphenyl-isothiocyanate (20 μL, 0.12 mmol) and 7-(4-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one (29 mg, 0.12 mmol) in anhydrous THF (2 mL) was stirred at room temperature for 3 days. The solvent was evaporated and the solid residue was washed with DCM to afford the title compound (47 mg, 82%). 1H-NMR (δ, ppm, DMSO-d6): 6.40 (d, 1H, HPy,6, J=5.8 Hz), 7.15 (d, 2H, Harom,Ph,3+5, J=8.70 Hz), 7.54 (d, 2H, Harom,Ph,2+6, J=8.75 Hz), 7.67 (d, 1H, HPy,6, J=8.55 Hz), 7.80 (broad s, 2H, Harom′), 8.08 (s, 1H, Harom′), 10.03 (s, 1H, NHthiourea,1), 10.10 (s, 1H, NHthiourea,3), 11.18 (s, 1H, NHPy3), 11.36 (s, 1H, NHPy2).

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