반응 #1951506

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L-(+)-lactic acid

N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[(1R)-1-methyl-2-(methylamino)ethoxy]quinazolin-4-amine

→

title compound

수율 35.0%

(2S)-N-{(2R)-2-[(4-{[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-5-yl)oxy]propyl}-2-hydroxy-N-methylpropanamide

수율 35.0%

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실험 절차

The procedure described in Example 1 was repeated using L-(+)-lactic acid and N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[(1R)-1-methyl-2-(methylamino)ethoxy]quinazolin-4-amine (obtained as described in Example 2.3, preparation of starting materials) to give the title compound as a white solid in 35% yield; NMR spectrum (DMSO-d6 373K) 1.07 (d, 3H), 1.45 (d, 3H), 2.98 (s, 3H), 3.22 (m, 1H), 4.19 (m, 1H), 4.43 (m, 1H), 5.15 (m, 1H), 5.27 (s, 2H), 7.22 (m, 2H), 7.35 (m, 2H), 7.59 (m, 2H), 7.69 (t, 1H), 7.84 (dt, 1H), 8.08 (d, 1H), 8.47 (s, 1H), 8.58 (d, 1H), 9.93 (s, 1H); Mass spectrum MH+ 522.

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