반응 #1951432

반응 방정식

N-[(2R)-2-({4-[(3-chloro-4-hydroxyphenyl)amino]quinazolin-5-yl}oxy)propyl]-N-methylacetamide

3-fluorobenzyl chloride

→

title compound

수율 87.0%

N-((2R)-2-{[4-({3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)quinazolin-5-yl]oxy}propyl)-N-methylacetamide

수율 87.0%

반응 조건

실험 절차

The procedure described in Example 3 was repeated using N-[(2R)-2-({4-[(3-chloro-4-hydroxyphenyl)amino]quinazolin-5-yl}oxy)propyl]-N-methylacetamide (obtained as described for in Example 50, preparation of starting materials) and 3-fluorobenzyl chloride to give the title compound in 87% yield; NMR spectrum (DMSO-d6) 1.36 (d, 3H), 1.93 (s, 3H), 3.04 (s, 3H), 3.27 (1H obscured by H2O), 4.22 (dd, 1H), 5.07 (m, 1H), 5.25 (s, 2H), 7.16 (t, 1H), 7.29 (m, 5H), 7.45 (m, 1H), 7.65 (dd, 1H), 7.71 (t, 1H), 8.09 (d, 1H), 8.46 (s, 1H), 9.93 (s, 1H); Mass Spectrum MH+ 509.

출처