반응 #1951428

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methoxyacetic acid

N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[(1S)-1-methyl-2-(methylamino) ethoxy]quinazolin-4-amine

→

title compound

수율 39.0%

N-{(2S)-2-[(4-{[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-5-yl)oxy]propyl}-2-methoxy-N-methylacetamide

수율 39.0%

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후처리

1. 1
   기타obtained
2. 2
   기타as described for the R-antipode in Example 2.3, preparation of starting materials)

실험 절차

The procedure described in Example 1 was repeated using methoxyacetic acid and N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[(1S)-1-methyl-2-(methylamino) ethoxy]quinazolin-4-amine (obtained as described for the R-antipode in Example 2.3, preparation of starting materials) to give the title compound in 39% yield; NMR spectrum (DMSO-d6) 1.38 (d, 3H), 2.99 (s, 3H), 3.16 (s, 3H), 3.27 (1H obscured by H2O), 4.03 (s, 2H), 4.23 (m, 1H), 5.11 (m, 1H), 5.29 (s, 2H), 7.24 (m, 2H), 7.30 (d, 1H), 7.35 (m, 1H), 7.57 (d, 1H), 7.65, (dd, 1H), 7.71 (t, 1H), 7.86 (dt, 1H), 8.12 (d, 1H), 8.44 (s, 1H), 8.58 (d, 1H), 9.90 (s, 1H); Mass Spectrum MH+ 522.

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