반응 #1951116

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5-chloro[1,2,4]triazolo[1,5-c]pyrimidine

hydrazine monohydrate

→

title compound

5-Hydrazino[1,2,4]triazolo[1,5-c]pyrimidine

용매

ethanol

ethanol

반응 조건

후처리

1. 1
   기타A white precipitate separated during the addition
2. 2
   기타the solid was collected on a filter
3. 3
   기타The solid was then collected on
4. 4
   여과a filter
5. 5
   세척washed with some additional concentrated ammonium hydroxide
6. 6
   기타After drying

실험 절차

A solution of 155 mg (1 mmol) of 5-chloro[1,2,4]triazolo[1,5-c]pyrimidine [D. J. Brown and K. Shinozuka, Aust. J. Chem., 33, 1147 (1980)] in 6 mL of dry ethanol was added gradually to a vigorously stirred solution of 198 mg (204 mg, 4 mmol) of hydrazine monohydrate in 2 mL of dry ethanol. A white precipitate separated during the addition. After 1.5 h, the solid was collected on a filter. It was suspended in 2 mL of concentrated ammonium hydroxide and agitated for a few minutes. The solid was then collected on a filter and washed with some additional concentrated ammonium hydroxide, then with some ethanol, and finally with a large volume of diethyl ether. After drying, the title compound was obtained as a white solid, mp 245-246° C. (decomposition). LC-MS 151 (M+1).

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