반응 #1951042

반응 방정식

tetrabutylammonium fluoride

acetic acid

Compound 22

5′-O-t-butyldimethylsilyl-2′,3′-dideoxy-4′-C-triethylsilylethynyl-2-fluoroadenosine

→

2′,3′-dideoxy-4′-C-ethynyl-2-fluoroadenosine

용매

tetrahydrofuran

tetrahydrofuran

반응 조건

후처리

1. 1
   기타reaction mixture
2. 2
   농축the resultant mixture was concentrated under reduced pressure
3. 3
   기타The thus-obtained residue was purified by means of silica gel column chromatography (silica gel 15 ml, chloroform:methanol=40:1 to 20:1)

실험 절차

Compound 22 (101 mg, 0.200 mmol) was dissolved in tetrahydrofuran (10 ml), and a solution of 1-M tetrabutylammonium fluoride in tetrahydrofuran (0.42 ml, 0.42 mmol) was added to the resultant solution, followed by stirring at room temperature for five minutes. After acetic acid (24 μl) was added to the resultant reaction mixture, the resultant mixture was concentrated under reduced pressure. The thus-obtained residue was purified by means of silica gel column chromatography (silica gel 15 ml, chloroform:methanol=40:1 to 20:1), to thereby yield compound 23 (53.0 mg, 0.191 mmol, 95.7%).

출처