반응 #1946544

반응 방정식

N-Bromosuccinimide

benzoyl peroxide

p-Toluene boronic acid

neopentyl glycol

→

p-bromomethyl phenyl boronic acid-neopentyl ester

용매

cyclohexane

cyclohexane

반응 조건

후처리

1. 1
   온도heated
2. 2
   온도at reflux for 1.5 hours
3. 3
   온도the solution was heated
4. 4
   온도at reflux for additional 2 hours
5. 5
   여과filtered
6. 6
   기타evaporated
7. 7
   기타to give

실험 절차

p-Toluene boronic acid (750 mg.) and neopentyl glycol (600 mg.) were dissolved in 50 ml cyclohexane and heated at reflux for 1.5 hours. N-Bromosuccinimide (1.15 g.), benzoyl peroxide (25 mg.) and 150 ml cyclohexane were added and the solution was heated at reflux for additional 2 hours. The solution was cooled to room temperature, filtered and evaporated to give a mixture of 8 and 8a (total of 1.3 g, ˜1:1 ratio), the yield of 8=47%.

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