반응 #1933448

반응 방정식

7-fluoro-1H-benzo[d][1,3]oxazine-2,4-dione

4-(sec-butyl)-aniline

4-sec-butyl aniline

→

2-amino-N-(4-sec-butyl-phenyl)-4-fluoro-benzamide

용매

DMF

반응 조건

후처리

1. 1
   추출The product was extracted with ethyl acetate
2. 2
   세척washed with brine
3. 3
   기타The solvent was evaporated in vacuo
4. 4
   기타to leave a crude material which
5. 5
   기타was purified by column chromatography (silica gel; 230-400 mesh; ethyl acetate/hexane=1:9)

실험 절차

To a solution of 7-fluoro-1H-benzo[d][1,3]oxazine-2,4-dione (1.00 g, 5.52 mmol) in anhydrous DMF (15 mL), 4-(sec-butyl)-aniline (B) (0.824 g, 5.52 mmol) was added and the reaction mixture was heated at 116° C. for 16 hours. The product was extracted with ethyl acetate and washed with brine. The solvent was evaporated in vacuo to leave a crude material which was purified by column chromatography (silica gel; 230-400 mesh; ethyl acetate/hexane=1:9) to give 2-amino-N-(4-sec-butyl-phenyl)-4-fluoro-benzamide (N) as white solid. Yield: 0.92 g (58%).

출처