반응 #1933441

반응 방정식

4-sec-butyl aniline

isatoic anhydride

water

→

2-amino-N-(4-sec-butylphenyl)benzamide

용매

DMF

반응 조건

후처리

1. 1
   온도It was then cooled to room temperature
2. 2
   추출extracted with ethyl acetate (200 mL)
3. 3
   세척The organic phase was washed with water (100 mL), 10% aqueous NaOH solution (100 mL), water (100 mL)
4. 4
   건조dried over anhydrous Na2SO4
5. 5
   기타Removal of solvent

실험 절차

4-sec-butyl aniline (B) (1.49 g, 10.0 mmol) was added to a solution of isatoic anhydride (A) (1.63 g, 10.0 mmol) in anhydrous DMF (40 mL) and the reaction mixture was stirred at 115° C. for 16 hours under nitrogen. It was then cooled to room temperature and poured into water (200 mL), and extracted with ethyl acetate (200 mL). The organic phase was washed with water (100 mL), 10% aqueous NaOH solution (100 mL), water (100 mL) and dried over anhydrous Na2SO4. Removal of solvent gave 2-amino-N-(4-sec-butylphenyl)benzamide (C) as a brown solid. Yield: 1.27 g (47%).

출처