반응 #1933

반응 방정식

KCN

3,4-dichlorobenzaldehyde

→

expected product

수율 100.5%

2-(3,4-Dichlorophenyl)-2-hydroxyacetonitrile

수율 100.5%

용매

water

water

반응 조건

후처리

1. 1
   온도the mixture is heated at 40°-45° C. for 1 hour
2. 2
   workup.WAITAfter one night at room temperature
3. 3
   온도the reaction mixture is cooled
4. 4
   추출extraction
5. 5
   세척the extract is washed with water
6. 6
   건조dried over MgSO4
7. 7
   기타evaporated under vacuum

실험 절차

25 g of 3,4-dichlorobenzaldehyde are added to a solution of 32.5 g of Na2S2O5 in 100 ml of water and the mixture is heated at 40°-45° C. for 1 hour. After one night at room temperature, the reaction mixture is cooled and a solution of 19.5 g of KCN in 40 ml of water is added slowly. After stirring for 30 minutes at RT, extraction is carried out with ether and the extract is washed with water, dried over MgSO4 and evaporated under vacuum to give 29 g of the expected product, which is used as such in the next step.

출처