반응 #1932414

반응 방정식

4′-methyl-5-((6-methylpyridin-3-yl)methylcarbamoyl)biphenyl-3-carboxylic acid

2,2,2-trifluoro-N-methylethanamine hydrochloride

N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate

N,N-diisopropylethylamine

→

final product

N3,4′-Dimethyl-N5-((6-methylpyridin-3-yl)methyl)-N3-(2,2,2-trifluoroethyl)biphenyl-3,5-dicarboxamide

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   기타The reaction mixture was purified by preparative HPLC

실험 절차

To a solution of 4′-methyl-5-((6-methylpyridin-3-yl)methylcarbamoyl)biphenyl-3-carboxylic acid (50 mg, 0.14 mmol) in N,N-dimethylformamide (1.5 mL) were added 2,2,2-trifluoro-N-methylethanamine hydrochloride (60 mg, 0.40 mmol), N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (120 mg, 0.32 mmol) and N,N-diisopropylethylamine (0.50 mL, 2.87 mmol). The reaction mixture was stirred for 16 hours at 25° C. The reaction mixture was purified by preparative HPLC to afford the final product as a light yellow solid.

출처