반응 #1932393

반응 방정식

5-(ethoxycarbonyl)-4′-methylbiphenyl-3-carboxylic acid

N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

1-hydroxybenzotriazole hydrate

(6-methylpyridin-3-yl)methanamine

N,N-diisopropylethylamine

→

Ethyl 4′-methyl-5-((6-methylpyridin-3-yl)methylcarbamoyl)biphenyl-3-carboxylate

용매

CH2Cl2

반응 조건

후처리

1. 1
   세척washed with water and aq. Na2CO3 solution
2. 2
   건조dried (Na2SO4)
3. 3
   농축concentrated in vacuo
4. 4
   기타The residue was purified by silica gel column
5. 5
   기타to afford a white foam

실험 절차

To a mixture of 5-(ethoxycarbonyl)-4′-methylbiphenyl-3-carboxylic acid (1.5 g, 5.3 mmol), N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (2.0 g, 10 mmol), 1-hydroxybenzotriazole hydrate (0.32 g, 2.1 mmol), and CH2Cl2 (50 mL) were added (6-methylpyridin-3-yl)methanamine (0.97 g, 7.9 mmol) and N,N-diisopropylethylamine (1.8 mL, 10 mmol). The mixture was stirred at room temperature for 4 h, and then washed with water and aq. Na2CO3 solution, dried (Na2SO4), and concentrated in vacuo. The residue was purified by silica gel column to afford a white foam.

출처