반응 #1932375

반응 방정식

4′-methyl-5-(methylsulfonyl)biphenyl-3-carboxylic acid

N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

1-hydroxybenzotriazole hydrate

(6-methylpyridin-3-yl)methanamine

N,N-diisopropylethylamine

→

4′-Methyl-N-((6-methylpyridin-3-yl)methyl)-5-(methylsulfonyl)biphenyl-3-carboxamide

용매

CH2Cl2

반응 조건

후처리

1. 1
   농축concentrated
2. 2
   기타The residue was purified by preparative HPLC (100×20.2 mm, C18 column; 30-80% CH3CN-water[10 mM Et2NH])
3. 3
   기타to afford a white solid

실험 절차

To a mixture of 4′-methyl-5-(methylsulfonyl)biphenyl-3-carboxylic acid (40 mg, 0.14 mmol), N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (53 mg, 0.28 mmol), 1-hydroxybenzotriazole hydrate (21 mg, 0.14 mmol), and CH2Cl2 (3 mL) were added (6-methylpyridin-3-yl)methanamine (25 mg, 0.21 mmol), and N,N-diisopropylethylamine (48 μL, 0.28 mmol). The mixture was stirred at room temperature overnight and then concentrated. The residue was purified by preparative HPLC (100×20.2 mm, C18 column; 30-80% CH3CN-water[10 mM Et2NH]) to afford a white solid.

출처