반응 #1929101

반응 방정식

4-[4-(1-oxo-but-2-ynylamino)-benzenesulfonyl]-piperazine-1-carboxylic acid tert-butyl ester

→

title compound

수율 44.4%

4-(4-(Z)-But-2-enoylamino-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester

수율 44.4%

용매

methanol

반응 조건

후처리

1. 1
   여과After this time, the reaction mixture was filtered through celite
2. 2
   농축concentrated under vacuum

실험 절차

Lindlar's catalyst (0.005 g, 0.001 mmol) was added in one portion to a stirred solution of 4-[4-(1-oxo-but-2-ynylamino)-benzenesulfonyl]-piperazine-1-carboxylic acid tert-butyl ester (0.05 g, 0.11 mmol) in methanol (5 ml) at room temperature, the resulting mixture was then stirred at room temperature under a hydrogen atmosphere for 2 hours. After this time, the reaction mixture was filtered through celite and concentrated under vacuum to give the title compound (0.02 g, 40% yield) as a white solid.

출처