반응 #1929099

반응 방정식

4-(4-Amino-benzenesulfonyl)-piperazine-1-carboxylic acid benzyl ester

diisopropylethylamine

acryloyl chloride

→

title compound

수율 20.0%

4-(4-Acryloylamino-benzenesulfonyl)-piperazine-1-carboxylic acid benzyl ester

수율 20.0%

용매

THF

반응 조건

후처리

1. 1
   기타The THF was removed under vacuum
2. 2
   기타the resulting crude material was purified by column chromatography (elution: 20% heptane, 80% ethyl acetate)

실험 절차

4-(4-Amino-benzenesulfonyl)-piperazine-1-carboxylic acid benzyl ester (0.25 g, 0.67 mmol) was dissolved in THF (10 ml). To this was added diisopropylethylamine (0.33 ml, 1.9 mmol) in one portion followed by the drop wise addition of acryloyl chloride (0.06 ml, 0.74 mmol) and the mixture was stirred at room temperature under a nitrogen atmosphere for 3 hours. The THF was removed under vacuum and the resulting crude material was purified by column chromatography (elution: 20% heptane, 80% ethyl acetate) to give the title compound (57 mg, 20% yield) as a white powder.

출처