반응 #1929093

반응 방정식

Ester

t-Butyl 3,3-bis(diethylphosphono)propanoate

→

Acid 41

3,3-bis(diethylphosphono)propanoic acid

용매

TFA

반응 조건

후처리

1. 1
   농축concentrated under reduced pressure
2. 2
   기타Crude acid 41 was purified by flash chromatography (gradient elution 100% ethyl acetate-10% methanol/ethyl acetate)

실험 절차

Ester 40 (2.1 g, 5.2 mmol) was stirred in TFA (12 mL) for 2.5 min and concentrated under reduced pressure. Crude acid 41 was purified by flash chromatography (gradient elution 100% ethyl acetate-10% methanol/ethyl acetate). Acid 41 was obtained as a white solid (1.35 g, 75%). 1H NMR (400 MHz, CDCl3) δ 1.28-1.39 (m, 12H), 2.86 (dt, J=16.1, 6.3, 2H), 3.12 (tt, J=24.0, 6.3, 1H), 4.13-4.26 (m, 8H).

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