반응 #1929076

반응 방정식

hydrogen chloride

potassium tert-butoxide

compound

Methyl 1-{[(5-bromo-2-methylphenyl)acetyl]amino}cyclohexanecarboxylate

water

→

3-(5-Bromo-2-methylphenyl)-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-one

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   온도After cooling
2. 2
   여과The precipitate was filtered off with suction
3. 3
   세척washed with water
4. 4
   기타dried

실험 절차

1.71 g (15.2 mmol) of potassium tert-butoxide were added to 2.80 g (7.60 mmol) of the compound from Example 12A in 15 ml of N,N-dimethylformamide. The reaction mixture was heated at 80° C. for 15 minutes. After cooling, water was added and aqueous hydrogen chloride solution was added dropwise. The precipitate was filtered off with suction, washed with water and dried. This gave 2.33 g (90% of theory) of the title compound.

출처