반응 #1929062

반응 방정식

HCl

potassium hydrogen carbonate

6-(chloracetamido) hexanoic acid

potassium cyanide

→

6-(cyanacetamido)hexanoic acid

용매

water

반응 조건

후처리

1. 1
   온도was cooled on ice
2. 2
   추출The residue after extraction
3. 3
   기타was purified by chromatography (silica gel, solvent: ethyl acetate)

실험 절차

2.8 g (20 mMol) potassium hydrogen carbonate was added to 8.3 g (40 mMol) 6-(chloracetamido) hexanoic acid dissolved in 25 ml water. 3.2 g (48 mMol) potassium cyanide was then added to the clear solution which was cooled on ice. The reaction mixture was stirred for 17 hours and was then acidified with HCl (2 N). The residue after extraction was purified by chromatography (silica gel, solvent: ethyl acetate).

출처