반응 #1929031

반응 방정식

trimethyl borate

dibenzoselenophene

HCl

BuLi

→

dibenzoselenophen-4-ylboronic acid

용매

ether

반응 조건

후처리

1. 1
   온도The reaction mixture was then heated
2. 2
   온도to reflux for 5 hours
3. 3
   workup.WAITIt was then left
4. 4
   추출The organic phase was extracted with ethyl acetate
5. 5
   건조dried with sodium sulfate
6. 6
   기타The combined organic phase was evaporated to dryness and 100 mL of 30% ethyl acetate in hexane
7. 7
   workup.ADDITIONwas added to the solid
8. 8
   workup.STIRRINGwith stirring at room temperature for 8 hours
9. 9
   여과The suspension was filtered
10. 10
    세척the solids were washed with hexane
11. 11
    기타dried
12. 12
    기타yielding 2 of white solids as the product which

실험 절차

4.0 g (17.3 mmol) of dibenzoselenophene and 150 mL of dry ether were added in a 250 mL three necked flask under nitrogen. To the mixture, 11.5 mL of BuLi (1.6 M in hexane) was added slowly at room temperature. The reaction mixture was then heated to reflux for 5 hours. The reaction mixture was cooled to −78° C. and 5 mL of trimethyl borate was added. It was then left to stir at room temperature for overnight. About 50 mL of 1 M HCl was added to the reaction mixture. The organic phase was extracted with ethyl acetate and dried with sodium sulfate. The combined organic phase was evaporated to dryness and 100 mL of 30% ethyl acetate in hexane was added to the solid with stirring at room temperature for 8 hours. The suspension was filtered, the solids were washed with hexane and dried, yielding 2 of white solids as the product which was confirmed by NMR

출처