반응 #1929022

반응 방정식

Benzoyl chloride

3-Nitrophenol

triethylamine

water

→

3-nitrophenyl benzoate

수율 90.3%

용매

dichloromethane

반응 조건

후처리

1. 1
   workup.STIRRINGthe resulting solution was shaken at room temperature until full conversion
2. 2
   건조The organic phase was dried over magnesium sulfate
3. 3
   여과filtered
4. 4
   기타the solvent was removed under reduced pressure

실험 절차

3-Nitrophenol (1.716 g, 12.346 mmol) and triethylamine (1.6 mL, 12.346 mmol) were dissolved in 50 mL of dichloromethane. The solution was shaken 30 minutes at room temperature. Benzoyl chloride (1.43 mL, 12.346 mmol) was added drop by drop and the resulting solution was shaken at room temperature until full conversion as determined by thin-layer chromatography. Carbonated water (20 mL) was added three times. The organic phase was dried over magnesium sulfate, filtered and the solvent was removed under reduced pressure, thus affording 2.7080 g of a white solid corresponding to 3-nitrophenyl benzoate (11.144 mmol, yield=90%).

출처