반응 #1929013

반응 방정식

triethyltrifluorovinylsilane

1-chloro-4-propylcyclohexane

4,4′-di-tert-butylbiphenyl

lithium

→

[(Z)-1,2-difluoro-2-(4-propylcyclohexyl)vinyl]triethylsilane

용매

Water

THF

반응 조건

후처리

1. 1
   workup.ADDITIONare added at 0° C
2. 2
   온도The mixture is warmed slowly
3. 3
   추출the batch is extracted with MTBE
4. 4
   추출The aqueous phase is extracted with MTBE
5. 5
   세척the combined organic phases are washed with water and saturated sodium chloride solution
6. 6
   기타The solution is dried
7. 7
   농축concentrated under reduced pressure
8. 8
   여과is filtered off
9. 9
   농축The filtrate is concentrated under reduced pressure
10. 10
    기타the residue is purified by column chromatography (SiO2, pentane)

실험 절차

74.1 g (0.28 mol) of 4,4′-di-tert-butylbiphenyl are initially introduced in 1000 ml of THF in an argon atmosphere, and 1.6 g (0.23 mol) of lithium (granules) are added at 0° C. After 5 h, the blue solution is cooled to −78° C., and 40.6 g (0.25 mol) of 1-chloro-4-propylcyclohexane are added. After 30 min at this temperature, 49.6 g (0.25 mol) of triethyltrifluorovinylsilane are metered in. The mixture is warmed slowly and stirred at room temperature for 16 h. Water is added, and the batch is extracted with MTBE. The aqueous phase is extracted with MTBE, and the combined organic phases are washed with water and saturated sodium chloride solution. The solution is dried using sodium sulfate and concentrated under reduced pressure. The residue is digested with methanol, and insoluble material is filtered off. The filtrate is concentrated under reduced pressure, and the residue is purified by column chromatography (SiO2, pentane), giving [(Z)-1,2-difluoro-2-(4-propylcyclohexyl)vinyl]triethylsilane as a colourless oil.

출처