반응 #1929010

반응 방정식

sodium bisulfite

sodium indole-2-sulfonate

acetic anhydride

→

sodium 1-acetylindole-2-sulfonate

수율 93.0%

반응 조건

후처리

1. 1
   온도The mixture was heated
2. 2
   workup.WAITat 90° C. for 2 hrs
3. 3
   온도Upon cooling
4. 4
   여과the solid was filtered
5. 5
   세척washed with ether
6. 6
   기타dried

실험 절차

To a round-bottom-flask containing 60 mL acetic anhydride was added 5 g sodium bisulfite and 5 g sodium indole-2-sulfonate. The mixture was heated and stirred at 70° C. for 1 hr and then at 90° C. for 2 hrs. Upon cooling, the solid was filtered, washed with ether, and dried to yield 5.7 g of sodium 1-acetylindole-2-sulfonate product (93%) as a white solid. The sodium 1-acetylindole-2-sulfonate product was used in the next step without further purification. MP>320° C.; IR (KBr, cm−1) 3480, 3010, 1660, 1490, 1400, 1385, 1150, 1050, 980, 760.

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