반응 #1927

반응 방정식

methyl 3-bromomethyl-2-thiophenecarboxylate

triphenylphosphine

→

2-methoxycarbonylthiophen-3-ylmethyltriphenylphosphonium bromide

수율 70.4%

용매

toluene

반응 조건

후처리

1. 1
   여과The precipitated crystals were collected by filtration
2. 2
   기타dried

실험 절차

To a solution of methyl 3-bromomethyl-2-thiophenecarboxylate (7.31 g, 31.1 mmol) in toluene (90 ml) was added triphenylphosphine (7.92 g, 30.2 mmol) under ice cooling. The temperature of the mixture was raised to room temperature, followed by stirring for 2 days. The precipitated crystals were collected by filtration and dried to give 2-methoxycarbonylthiophen-3-ylmethyltriphenylphosphonium bromide (10.57 g, 70.4%). This product was subjected to the reaction of Reference Example 13 without purification.

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