반응 #1925214

반응 방정식

acetic anhydride

N,N-bis(2-hydroxyethyl)-2-(methoxycarbonyl)ethylamine

triethylamine

THF

→

N,N-bis(2-acetoxyethyl)-2-(methoxycarbonyl)ethylamine

수율 99.0%

용매

Water

반응 조건

후처리

1. 1
   기타to terminate
2. 2
   기타the reaction
3. 3
   추출The reaction mixture was extracted with ethyl acetate
4. 4
   세척The organic layer was then washed with water
5. 5
   건조dried over anhydrous sodium sulfate
6. 6
   농축After concentration under reduced pressure
7. 7
   workup.DISTILLATIONthe residue was purified by distillation under reduced pressure

실험 절차

At 20 to 30° C., acetic anhydride was added to a mixture of 9.29 g of N,N-bis(2-hydroxyethyl)-2-(methoxycarbonyl)ethylamine, 12.8 g of triethylamine, 50 mg of 4-dimethylaminopyridine and 50 ml of THF and the resulting mixture was stirred for 20 hours. Water was added to terminate the reaction. The reaction mixture was extracted with ethyl acetate. The organic layer was then washed with water and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the residue was purified by distillation under reduced pressure, whereby 13.2 g of N,N-bis(2-acetoxyethyl)-2-(methoxycarbonyl)ethylamine was obtained (boiling point: 118 to 123° C./21 Pa, yield: 99%).

출처