반응 #1925198

반응 방정식

hydrochloric acid

5-[4-(3-methyl-3-hydroxybutyne-1-yl)phenoxy]pentanol

toluene

sodium hydroxide

→

5-(4-ethynylphenoxy)pentanol

수율 98.1%

용매

ethyl acetate

water

반응 조건

후처리

1. 1
   기타A flask equipped with a stirrer
2. 2
   온도under reflux for 4 hours
3. 3
   workup.ADDITIONwere added to the reactant
4. 4
   추출to an acidity and effect ethyl acetate extraction
5. 5
   세척The resulting organic phase was washed with NaCl saturated water
6. 6
   건조dried over anhydrous sodium sulfate
7. 7
   여과filtered
8. 8
   농축concentrated

실험 절차

A flask equipped with a stirrer and a thermometer was charged with 5.41 g (20.6 mmol) of 5-[4-(3-methyl-3-hydroxybutyne-1-yl)phenoxy]pentanol and 70 ml of toluene under a nitrogen atmosphere. To the flask, 1.65 g (41.2 mmol) of sodium hydroxide was added, and stirred under reflux for 4 hours. After the completion of the reaction, water, 1N hydrochloric acid, and ethyl acetate were added to the reactant to adjust the pH to an acidity and effect ethyl acetate extraction. The resulting organic phase was washed with NaCl saturated water, dried over anhydrous sodium sulfate, filtered, and concentrated to thereby obtain 4.13 g of 5-(4-ethynylphenoxy)pentanol in the form of a brown oil in a 98% yield.

출처