반응 #1922746

ord-b1895a8f4cd14b53a3a943308ffa8083

반응 방정식

O=C(N[C@@H](CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Fmoc Cha-OH
Clc1ccccc1C(Cl)(c1ccccc1)c1ccccc1
chlorotrityl chloride
O=C(N[C@@H](CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Fmoc-Cha
CC(C)NC(C)C
diisopropylamine

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Fmoc Cha-OH (1 mmol each time) was double coupled to the chlorotrityl chloride resin in the standard way using, dichloromethane (5 ml each time) with diisopropylamine (2 eq, 348 μl each time) to give Fmoc-Cha-resin.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06770627B1uspto-grants-2004_08