반응 #1916328

반응 방정식

4-Amino-3-bromobenzotrifluoride

potassium ethylxanthate

Water

→

6-trifluoromethyl-2-mercaptobenzothiazole

수율 25.8%

용매

N-methyl-2-pyrrolidone

반응 조건

후처리

1. 1
   온도with heating
2. 2
   추출the mixture was extracted with ethyl acetate
3. 3
   세척The extract was washed successively with water and brine
4. 4
   농축concentrated under reduced pressure

실험 절차

4-Amino-3-bromobenzotrifluoride (2.40 g) was dissolved in N-methyl-2-pyrrolidone (10 mL), and potassium ethylxanthate (3.52 g) was added thereto. The mixture was stirred at 160° C. for 3 hr with heating. Water (300 mL) was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed successively with water and brine, and concentrated under reduced pressure to give 6-trifluoromethyl-2-mercaptobenzothiazole (607 mg) as an orange powder.

출처