반응 #1915662

반응 방정식

tert-butyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenoate

( D )

tert-Butyl (E)-3-(8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-morpholino-4-oxo-4-H-pyrido[1,2-a]pyrimidin-3-yl)-2-propenoate

→

title compound

수율 86.4%

(E)-3-{8-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-morpholino-4-oxo-4 H-pyrido-[1,2-a]pyrimidin-3-yl}-2-propenoic acid

수율 86.4%

용매

formic acid

반응 조건

후처리

1. 1
   기타the solvent was evaporated under reduced pressure

실험 절차

The tert-butyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenoate (39 mg) obtained in (D) was stirred in formic acid (1 ml) for 4.5 hours, and the solvent was evaporated under reduced pressure to obtain the title compound (30 mg).

출처