반응 #1912875
ord-e2b222811baf4d4a886cc0be4c38af81
반응 조건
후처리
- 1기타were prepared
- 2기타Pre-spray drying solutions
- 3기타were prepared
- 4농축Final total solute concentration of the solution
- 5기타drying
- 6기타was prepared
- 7workup.ADDITIONmixing the two solutions
- 8기타to yield one liter of cosolvent with a total solute concentration of 1 g/L (w/v)
- 9농축Higher solute concentrations of 3 g/L (w/v)
- 10기타were prepared
- 11기타The solution was spray-dried
- 12workup.ADDITIONcontaining formulation
- 13기타was from about 110° C. to about 140° C.
- 14기타ranged from about 45–57° C.
실험 절차
The albuterol sulfate powder formulations listed in Table 7, were prepared as follows. Pre-spray drying solutions were prepared by dissolving the lipid in ethanol and albuterol sulfate and leucine in water. The ethanol solution was then mixed with the water solution at a ratio of 70/30 ethanol/water. Final total solute concentration of the solution used for spray drying varied from 1 g/L to 3 g/L. As an example, the DPPC/leucine/albuterol sulfate (76/16/8) spray drying solution was prepared by dissolving 760 mg of DPPC in 700 mL of ethanol, dissolving 160 mg leucine and 870 mg of albuterol sulfate in 300 mL water and then mixing the two solutions to yield one liter of cosolvent with a total solute concentration of 1 g/L (w/v). Higher solute concentrations of 3 g/L (w/v) were prepared by dissolving three times more of each solute in the same volumes of ethnaol and water. The solution was spray-dried as described above for the insulin containing formulation. Specifically, the inlet temperature was from about 110° C. to about 140° C., and the outlet temperature ranged from about 45–57° C.