반응 #1909791
ord-629b7224b37c4aacbd88982eeb240429
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1추출the mixture was extracted with ethyl acetate
- 2세척The organic layer was washed successively with a 10 % aqueous citric acid solution, water
- 3건조a saturated aqueous sodium hydrogen-carbonate solution, water and saturated brine, dried over magnesium sodium sulfate
- 4농축concentrated under reduced pressure
실험 절차
To a solution of 4-(4-hydroxyphenyl)benzoic acid (3.0 g) and L-phenylalanine ethyl ester hydrochloride (3.38 g) in DMF (30 ml) were added WSC.HCl (2.7 g), HOBT (1.89 g) and triethylamine (2 ml), and the mixture was stirred at room temperature for 14 hours. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed successively with a 10 % aqueous citric acid solution, water, a saturated aqueous sodium hydrogen-carbonate solution, water and saturated brine, dried over magnesium sodium sulfate, and concentrated under reduced pressure to give a crude product of the title compound.