반응 #1909789

반응 방정식

hydrogen

( 1 )

4-[4-(tert-Butoxycarbonylmethylamino)-1-butenyl]-2-hydroxybenzoic acid methyl ester

→

title compound

수율 95.0%

4-[4-(tert-Butoxycarbonylmethylamino)butyl]-2-hydroxybenzoic acid methyl ester

수율 95.0%

용매

methanol

반응 조건

후처리

1. 1
   여과After filtering through Celite
2. 2
   농축the mixture was concentrated under reduced pressure
3. 3
   기타the residue was purified by silica gel column chromatography (developing solvent: hexane/ethyl acetate=4/1 v/v)

실험 절차

A solution of the compound (0.845 g) obtained in (1) above in methanol (20 ml) was vigorously stirred in the presence of 10% palladium-carbon (0.106 g) in a stream of hydrogen. After filtering through Celite, the mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (developing solvent: hexane/ethyl acetate=4/1 v/v) to give the title compound (0.810 g, yield 95%).

출처