반응 #1909787

반응 방정식

3,4-dichloro-2,4-dihydroxybenzoic acid

L-phenylalanine methyl ester hydrochloride

WSC.HCl

HOBT

→

title compound

수율 63.1%

N-(3,5-Dichloro-2,4-dihydroxybenzoyl)-L-phenylalanine methyl ester

수율 63.1%

용매

DMF

triethylamine

반응 조건

후처리

1. 1
   workup.ADDITIONThen, the mixture was post-treated in the same manner as in the above Example 1, (Step 5)

실험 절차

To a solution of 3,4-dichloro-2,4-dihydroxybenzoic acid (17 g), L-phenylalanine methyl ester hydrochloride (19.8 g), WSC.HCl (17.6 g) and HOBT (12.4 g) in DMF (70 ml) was added dropwise triethylamine (12.8 ml) at room temperature, and the mixture was stirred for 16 hours. Then, the mixture was post-treated in the same manner as in the above Example 1, (Step 5) to give the title compound (18.32 g, yield 57%).

출처